Table 1.
Association results for prostate cancer risk variants at 13q34 and 22q12.1 in men of African ancestry
| SNP ID chr. position* | Nearby genes | AAPC |
Ghana |
Kaiser/ProHealth |
ELLIPSE OncoArray |
Meta-analysis |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Alleles† | OR (95% CI) | P† | RAF§ | OR (95% CI) | P‡ | RAF§ | OR (95% CI) | P‡ | RAF§ | OR (95% CI) | P‡ | RAF§ | OR (95% CI) | P‡ | ||
| rs75823044 | IRS2 | T/C | 1.47 (1.22 to 1.76) | 3.73 × 10‐5 | 0.022 | 2.66 (1.59 to 4.47) | 2.04 × 10-4 | 0.029 | 1.27 (0.80 to 2.00) | .31 | 0.021 | 1.60 (1.31 to 1.96) | 4.84 × 10-6 | 0.020 | 1.55 (1.37 to 1.76) | 6.10 × 10-12 |
| 13q34 | ||||||||||||||||
| 110,360,784 | ||||||||||||||||
| rs78554043 | CHEK2 | C/G | 1.60 (1.27 to 2.00) | 5.02 × 10‐5 | 0.015 | 2.45 (1.33 to 4.52) | .004 | 0.019 | 1.17 (0.69 to 1.99) | .55 | 0.017 | 1.66 (1.30 to 2.13) | 5.98 × 10-5 | 0.013 | 1.62 (1.39 to 1.89) | 7.50 × 10-10 |
| 22q12.1 | ||||||||||||||||
| 28,374,943 | ||||||||||||||||
*
Genome build 37/HG19. chr. = chromosome; CI = confidence interval; OR = odds ratio; RAF = risk allele frequency.
†
Risk allele/reference allele.
‡
Allele dosage effects were tested through a 1-degree of freedom Wald trend test. All P values are two-sided.
§
Risk allele frequency in controls.