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Effects of intracellular Ca2+-buffering by BAPTA. If PC-12 cells were preloaded with 10 μM BAPTA, the neuroprotective effect of xenon was strongly reduced. At the same time, however, a small reduction in cellular damage was observed in nitrogen-treated cells. (n = 5; P < 0.0001 analyzed by 2-way ANOVA and Bonferroni posttests between BAPTA-treated and untreated groups; no significant difference was found when the nitrogen-group was compared to the nitrogen-BAPTA group).
