Table 1.
Clinicopathologic properties according to Siewert classification
| Properties | Siewert I | Siewert II | Siewert III | p |
|---|---|---|---|---|
| Gender | ||||
| Female | 3 (15.7) | 11 (27.5) | 43 (33.5) | |
| Male | 16 (84.3) | 29 (72.5) | 85 (66.5) | 0.2 |
| Age | ||||
| ≤50 | 4 (21) | 3 (7.5) | 20 (15.6) | |
| >50 | 15 (79) | 37 (92.5) | 108 (84.4) | 0.3 |
| Histopathology | ||||
| Mucinous adenocarcinoma | 12 (63.1) | 30 (75) | 100 (78.1) | |
| Signet ring cell | 2 (10.5) | 3 (7.5) | 9 (7) | |
| Carcinoma | 5 (26.4) | 7 (17.5) | 15 (11.7) | |
| Mixed | 0 | 0 | 4 (3.2) | 0.4 |
| Lymph node dissection | ||||
| D0 | 2 (10.5) | 2 (5) | 3 (2.3) | |
| D1 | 9 (47.5) | 11 (27.5) | 50 (39) | |
| D2 | 4 (21) | 16 (40) | 50 (39) | |
| D3 | 4 (21) | 11 (27.5) | 25 (19.7) | 0.001 |
| T stage | ||||
| T0 | 1 (5.2) | 0 | 0 | |
| T1 | 0 | 0 | 3 (2.3) | |
| T2 | 2 (10.5) | 2 (5) | 35 (27.3) | |
| T3 | 4 (21) | 21 (52.5) | 44 (34.3) | |
| T4 | 12 (63.6) | 17 (42.5) | 46 (36.1) | 0.001 |
| N stage | ||||
| N0 | 4 (21) | 7 (17.5) | 26 (20.3) | |
| N1 | 3 (16) | 5 (12.5) | 34 (26.5) | |
| N2 | 4 (21) | 10 (25) | 38 (29.6) | |
| N3 | 8 (42) | 18 (45) | 30 (23.6) | 0.1 |
| Stage | ||||
| 1 | 1 (5.2) | 0 | 12 (9.3) | |
| 2 | 3 (16) | 9 (22.5) | 41 (32) | |
| 3 | 11 (57.8) | 27 (67.5) | 72 (56.2) | |
| 4 | 4 (21) | 4 (10) | 3 (2.5) | 0.006 |
| LI | ||||
| Absent | 3 (16) | 11 (27.5) | 36 (28.1) | |
| Present | 14 (73.5) | 29 (72.5) | 88 (68.7) | |
| Unknown | 2 (10.5) | 0 | 4 (3.2) | 0.2 |
| VI | ||||
| Absent | 4 (21) | 15 (37.5) | 37(28.9) | |
| Present | 13 (68.5) | 23 (57.5) | 85 (66.4) | |
| Unknown | 2 (10.5) | 2 (5) | 6 (4.7) | 0.5 |
| PNI | ||||
| Absent | 5 (26.3) | 11 (27.5) | 32 (25) | |
| Present | 13 (68.5) | 28 (70) | 90 (70.3) | |
| Unknown | 1 (5.2) | 1 (2.5) | 6 (4.7) | 0.9 |
| Borrmann classification | ||||
| Type 1 (polipoid) | 1 (10.2) | 0 | 2 (1.5) | |
| Type 2 (fungating) | 0 | 2 (5) | 2 (1.5) | |
| Type 3 (ulcerated) | 15 (73.8) | 33 (82.5) | 105 (82) | |
| Type 4 (diffuse infiltrative) | 3 (16) | 2 (5) | 5 (3.9) | |
| Unknown | 0 | 3 (7.5) | 14 (11.1) | 0.1 |
| Lauren classification | ||||
| Intestinal | 4 (21) | 9 (22.5) | 44 (34.3) | |
| Diffuse | 3 (16) | 2 (5) | 27 (21) | |
| Mixed | 1(10.2) | 4 (10) | 3 (2.3) | |
| Unknown | 11 (52.8) | 25 (62.5) | 54 (42.4) | 0.03 |
| Grade | ||||
| 1 | 0 | 0 | 9 (7.2) | |
| 2 | 5 (26.3) | 18 (45) | 56 (43.7) | |
| 3 | 14 (73.7) | 19 (47.5) | 60 (46.8) | |
| Unknown | 0 | 3 (7.5) | 3(2.3) | 0.08 |
| Surgical margin | ||||
| Positive | 4 (21) | 15 (37.5) | 26 (20.4) | |
| Negative | 15 (79) | 25 (62.5) | 102 (79.6) | 0.08 |
| Metastasis | ||||
| Present | 6 (31.5) | 6 (15) | 6 (4.6) | |
| Absent | 13 (68.5) | 34 (85) | 122 (95.4) | <0.001 |
| Preoperative CT-RT | ||||
| Present | 9 (47.3) | 5 (12.5) | 0 | |
| Absent | 10 (52.8) | 35 (87.5) | 128 (100) | <0.001 |
| Recurrence | ||||
| Present | 8 (42.1) | 21 (52.5) | 65 (50.7) | |
| Absent | 11 (47.9) | 19 (47.5) | 63 (49.3) | 0.7 |
| Type Of Surgery | ||||
| Total Gastrectomy | 12(63.1) | 39 (97.5) | 93 (72.6) | |
| Proximal Gastrectomy | 7 (36.9) | 1 (2.5) | 35 (27.4) | 0.02 |
LI: lymphatic invasion; VI: vascular invasion; PNI: perineural invasion; CT: chemotherapy; RT: radiotherapy
Datas are presented as n (%).