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. 2017 May 5;108(5):809–817. doi: 10.1111/cas.13208

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© 2017 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Hypothetical model for the mitochondria‐eating protein (Mieap)‐induced vacuole (MIV) mechanism. Severely damaged and dangerous mitochondria produce very high levels of reactive oxygen species (ROS), which are extremely toxic to the cell. These ROS induce the generation of MIVs. The MIVs uptake and degrade the dangerous mitochondria to maintain cellular homeostasis. UV radiation resistance associated gene (UVRAG) protein mediates the MIV formation by interacting with Mieap. The endocytic pathway also plays a critical role in MIV formation. Lyso, lysosome.