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. 2017 Apr 27;108(5):918–930. doi: 10.1111/cas.13205

Figure 6.

Figure 6

Effects of GANT61 (0–20 μM) on the number of mammpspheres/1000 cells seeded in MCF‐7 cells (a), T‐47D cells (b), KPL‐1 cells (c) and KPL‐3C cells (d). Cells were treated with 1 nM E2 and the indicated concentrations of GANT61 for 6 days. The number of mammospheres/1000 cells was analyzed as described in the Materials and Methods. The values are means ± SE. White bars, control; the most light grey bars, E2 plus 1 μM GANT61; the second light gray bars, E2 plus 5 μM GANT61; the third light gray bars, E2 plus 10 μM GANT61; and the most dark grey bars, E2 plus 20 μM GANT61. *P < 0.05; **P < 0.01 in comparison with cells treated with E2 alone. In addition, representative results of the mammosphere assay in MCF‐7 cells treated with or without E2 plus minus 10 μM GANT61are shown in (e).