Table 2.
Hazards analysis of pathological prognostic factors in 911 patients underwent R0/1 resection
| No. of patients (%) n = 911 | Univariate analysis* | Multivariate analysis* | |||
|---|---|---|---|---|---|
| Hazard ratio (95% CI) | P‐value | Hazard ratio (95% CI) | P‐value | ||
| Borrmann classification | |||||
| Non‐Type 4 | 774 (85.0) | Reference | Reference | ||
| Type 4† | 137 (15.0) | 2.34 (1.88–2.90) | <0.001 | 1.88 (1.45–2.42) | <0.001 |
| Tumor size‡ | |||||
| 8.0> | 582 (63.9) | Reference | Reference | ||
| 8.0≤ | 329 (36.1) | 1.95 (1.63–2.34) | <0.001 | 1.33 (1.08–1.63) | 0.007 |
| Lauren classification | |||||
| Intestinal type | 368 (40.4) | Reference | Reference | ||
| Diffuse type | 543 (59.6) | 1.54 (1.27–1.87) | <0.001 | 1.24 (1.01–1.52) | 0.042 |
| Tumor depth§ | |||||
| T3 | 376 (41.3) | Reference | Reference | ||
| T4a | 483 (53.0) | 2.12 (1.73–2.60) | <0.001 | ||
| T4b | 52 (5.7) | 2.86 (1.97–4.15) | <0.001 | 1.54 (1.08–2.20) | 0.018 |
| Lymph‐node metastasis§ | |||||
| N0/1 | 366 (40.2) | Reference | Reference | ||
| N2/3 | 458 (50.3) | 2.48 (2.00–3.07) | <0.001 | ||
| Distant metastasis | 87 (9.5) | 4.95 (3.69–6.64) | <0.001 | 2.25 (1.73–2.93) | <0.001 |
| Lymphatic invasion | |||||
| Absent | 267 (29.3) | Reference | Reference | ||
| Present | 644 (70.7) | 1.84 (1.48–2.29) | <0.001 | 1.49 (1.18–1.87) | 0.001 |
| Venous invasion | |||||
| Absent | 152 (16.7) | Reference | Reference | ||
| Present | 759 (83.3) | 1.43 (1.11–1.84) | 0.006 | 1.48 (1.14–1.94) | 0.004 |
| Liver metastasis | |||||
| Absent | 891 (97.8) | Reference | Reference | ||
| Present | 20 (2.2) | 1.75 (1.05–2.93) | 0.033 | 1.93 (1.12–3.32) | 0.019 |
| Peritoneal metastasis | |||||
| Absent | 874 (95.9) | Reference | Reference | ||
| Present | 37 (4.1) | 2.08 (1.43–3.34) | <0.001 | 1.64 (1.11–2.41) | 0.013 |
| Peritoneal lavage cytology¶ | |||||
| Negative | 843 (92.5) | Reference | Reference | ||
| CYLow | 20 (2.2) | 1.14 (0.64–2.03) | 0.646 | ||
| CYHigh | 48 (5.3) | 4.47 (3.28–6.10) | <0.001 | 3.14 (2.29–4.31) | <0.001 |
*A Cox‐regression model was used for univariate and multivariate analyses. †Infiltrative growth pattern of the Borrmann's classification. ‡The cut‐off value of a tumor size influencing on poor prognosis was defined by receiver operating characteristic curve (Fig. S4). §TNM classification of International Union Against Cancer (UICC) 7th edition. ¶Among positive peritoneal lavage (CY+), the subgroup with presence of a signet ring cell (CY‐S), ≥5 cell clusters (CY‐C), or ≥50 isolated cancer cells (CY‐I) in peritoneal lavage fluid were defined as CYHigh and the remaining subgroup was defined as CYLow. CI, confidence interval.