Table S4.
Area under the curve and cutoff values of THBG, fibrinogen, and their combination
| Comparison | Area under the curve (95% confidence interval)
|
Cutoff value (sensitivity, specificity)
|
||||
|---|---|---|---|---|---|---|
| THBG | Fibrinogen | Combination | THBG | Fibrinogen | Combination | |
| COPD vs control | 0.814 (0.716–0.890) |
0.739 (0.633–0.828) |
0.858 (0.766–0.924) |
6.42 μg/mL (96.2%, 66.7%) |
2.603 g/L (84.9%, 57.6%) |
0.682 (69.8%, 90.9%) |
| GOLD I vs GOLD II–IV | 0.786 (0.652–0.887) |
0.623 (0.480–0.753) |
0.791 (0.657–0.890) |
8.14 μg/mL (69.8%, 80.0%) |
3.5 g/L (46.5%, 90.0%) |
0.6463 (88.4%, 60.0%) |
| GOLD I, II vs GOLD III, IV | 0.639 (0.495–0.766) |
0.616 (0.472–0.746) |
0.666 (0.523–0.789) |
8.66 μg/mL (60.7%, 64%) |
2.8 g/L (85.7%, 40.0%) |
0.435 (85.7%, 48.0%) |
| GOLD I–III vs GOLD IV | 0.851 (0.726–0.934) |
0.582 (0.439–0.716) |
0.848 (0.723–0.932) |
9.94 μg/mL (77.8%, 79.5%) |
3.6 g/L (55.6%, 72.7%) |
0.154 (77.8%, 79.5%) |
Abbreviations: COPD, chronic obstructive pulmonary disease; GOLD, Global Initiative for Obstructive Lung Disease; THBG, thyroxine-binding globulin.