Table S7.
HR of THBG for AE based on Cox proportional hazards models
| Variables | Cox proportional hazards models (enter method#)
|
|
|---|---|---|
| HR (95% CI) | P-value | |
| THBG_levela | 4.229 (1.131–15.814) | 0.032 |
| FEV1%pred | 0.976 (0.946–1.008) | 0.146 |
| Age, years | 0.921 (0.819–1.036) | 0.172 |
| Smoking history, pack-years | 1.007 (0.954–1.064) | 0.792 |
| Smoking cessation duration, years | 1.137 (0.954–1.355) | 0.153 |
| Hypertension | 0.668 (0.177–2.525) | 0.552 |
| Diabetes mellitus | 1.475 (0.177–12.303) | 0.719 |
Notes:
a
THBG_level: It was divided into the high- and low-level groups based on the median of THBG (8.66 μg/mL). It was still an independent risk factor (HR: 4.229, P=0.032) for AE, when THBG level, FEV1%pred, age, smoking history, smoking cessation duration, hypertension, and diabetes mellitus were corrected for.
#
Enter method means that all variables were included in Cox proportional hazards model.
Abbreviations: AE, acute exacerbation; CI, confidence interval; FEV1, forced expiratory volume in 1 s; HR, hazard ratio; pred, predicted; THBG, thyroxine-binding globulin.