Table S2.

Differentially expressed proteins^* between smokers with or without COPD

Accessiona	Abbreviation	Description	Change fold
Upregulated
B3KRN4	HTRA1	Serine protease HTRA1	1.28
P00739	HPTR	Haptoglobin-related protein	1.43
Q9UBX1	CATF	Cathepsin F	1.24
P19652	A1AG2	Alpha-1-acid glycoprotein 2	1.59
Q9UL89	MIHCVR	Myosin-reactive immunoglobulin heavy chain variable region	2.31
A0A087×0P6	IGKV2D-29	Protein IGKV2D-29	3.39
B3KS79	A1AC	Alpha-1-antichymotrypsin	1.39
P05543	THBG	Thyroxine-binding globulin	1.61
P05160	F13B	Coagulation factor XIII B chain	1.23
P02776	PLF4	Platelet factor 4	1.82
A0A0A0MS14	IGHV1-45	Protein IGHV1-45	2.31
Q5UGI6	SERPING1	Serine/cysteine proteinase inhibitor clade G member 1 splice variant 2	1.29
S6C4Q7	IGHC	IgG H chain	3.05
Downregulated
P27482	CALL3	Calmodulin-like protein 3	0.57
P23142	FBLN1	Fibulin-1	0.80
P18428	LBP	Lipopolysaccharide-binding protein	0.81
A2MYD4	A2MYD4	V2–7 protein (fragment)	0.71
Q53RT3	APRV1	Retroviral-like aspartic protease 1	0.47
P01608	KV116	Ig kappa chain V-I region Roy	0.61
P47929	Gal-7	Galectin-7	0.42
A0A075B730	EPPK1	Epiplakin	0.73
P01611	KV119	Ig kappa chain V-I region Wes	0.50
Q15084	PDIA6	Protein disulfide-isomerase A6	0.57
G3V2W1	SERPINA10	Protein Z-dependent protease inhibitor	0.74
B3KRF9	LP-54	Leucine-rich repeat-containing protein 54	0.81
H0Y7V6	PSPB	Pulmonary surfactant-associated protein B	0.76
Q7Z351	DKFZ	Putative uncharacterized protein DKFZp686N02209	0.49
P31151	S10A7	Protein S100-A7	0.43
G3V4U0	F-5	Fibulin-5	0.73
Q6U2E7	C4B1	C4B1 (fragment)	0.75
A8K6C1	CETP	Cholesteryl ester transfer protein, plasma	0.71
P55072	TERA	Transitional endoplasmic reticulum ATPase	0.80
A0A087WXL8	IGHG3	Ig gamma-3 chain C region	0.83
B4DF70	Per-2	Peroxiredoxin-2	0.64
B4DEW5	Mul-2	Multimerin-2	0.82
B4DTD5	FA	Filamin-A	0.57
P06727	APOA4	Apolipoprotein A-IV	0.81
P01781	HV320	Ig heavy chain V-III region GAL	0.78
P07237	PDIA1	Protein disulfide-isomerase	0.77
Q5FWF9	IGL	IGL@ protein	0.83
B5BU38	Ann	Annexin	0.65

Notes:

^*Differentially expressed proteins: the change fold is >1.2 and P-value is <0.05 by Student’s t-test.

^aThe accession of differentially expressed proteins is identified based on UniProt database.

Abbreviation: COPD, chronic obstructive pulmonary disease.