Table 1.

Cardiac function measurements on young adult and old mice.

Parameters	3 months	18 months
Body weight (g)	24.04 ± 1.47	23.59 ± 1.32
LV end diastole
IVS (mm)	0.89 ± 0.21	0.92 ± 0.16
LVID (mm)	2.95 ± 0.50	3.05 ± 0.46
LV PW (mm)	0.77 ± 0.09	0.89 ± 0.30
LV volume (μl)	34.93 ± 12.25	36.99 ± 12.57
LV end systole
IVS (mm)	1.58 ± 0.21	1.77 ± 0.41
LVID (mm)	1.35 ± 0.27	1.25 ± 0.17
LV PW (mm)	1.32 ± 0.14	1.50 ± 0.36
LV volume (μl)	4.96 ± 2.27	3.86 ± 1.24
Ejection fraction (%)	85.99 ± 3.58	88.16 ± 2.36
LV fraction shortening (%)	54.09 ± 4.56	58.81 ± 4.19
Mitral Pulse Doppler
E/A	1.79 ± 0.14	1.07 ± 0.20*
IVRT (ms)	12.91 ± 1.05	15.60 ± 0.95*
IVCT (ms)	7.66 ± 1.21	8.27 ± 0.87

Values are expressed as mean ± SE for each group. LV, left ventricle; IVS, intra-ventricular septum; LVID, left ventricular internal diameter; PW, posterior wall thickness of LV; IVRT, isovolumetric relaxation time; IVCT, isovolumetric contraction time. Statistical significance was determined by ANOVA followed by post hoc Newman-Keuls (SNK) tests.

^*P < 0.05, compared with 3 months group.