Table 6. Tolerance to the amino acid substitution in the epitopes targeted by VF-Fab1a-1-3.
| AN1 | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 393S | R | A | A | H | R | V | T | T | F | I | T | 405R |
| A | - | T | T | A | G | L | V | G | L | F | S | A |
| G | - | V | S | L | P | |||||||
| - | - | 1 | - | - | - | - | - | - | - | - | - | - |
| 1 | - | 0.34 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 |
| 0 | - | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Data presented is analysed and predicted using programme SIFT (http://sift.jcvi.org/www/SIFT_aligned_seqs_submit.html). Row corresponds to a position in the reference epitope. Column corresponds to amino acid variation (observed in our data set) at that position in different HCVpp (Fig 4A). Score at a particular position for an amino acid substitution is mentioned below the amino acid variant. The default threshold for functional intolerance used was 0.05 for amino acid substitution.