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. 2017 May 30;12(5):e0178221. doi: 10.1371/journal.pone.0178221

Fig 2. CBP-93872 enhances oxaliplatin-, cisplatin- and gemcitabine-induced apoptosis in HT29 cells or Panc-1 cells.

Fig 2

(A, B) HT29 cells were treated with oxaliplatin (30 μM) (A) or cisplatin (30 μM) (B) in the presence or absence of CBP-93872 (50 μM). Cells were harvested at 72 hrs, fixed and subjected to FACS analysis (left panels). The percentages of cells in sub-G1 phase are shown in the panels on the right. Data are presented as means ± SD (n = 3). Statistical significance was calculated using Student’s t-test (*, p < 0.01). (C) Panc-1 cells were treated with gemcitabine (0.1 μM) in the presence or absence of CBP-93872 (200 μM). (D-F) HT29 cells or Panc-1 cells, were collected at the times indicated. Total cell extracts were subjected to immunoblotting, using the indicated antibodies.