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. 2017 May 30;12(5):e0178064. doi: 10.1371/journal.pone.0178064

Table 1. Association between clinicopathological variables and immunohistochemical detection of HIF-1α.

Variables Number of patients HIF-1α P
Positive Negative
Clinical variables (n = 82)
NF1
 present 32 22 10 0.296
 absent 50 40 10
Age
 ≥50 37 30 7 0.317
 <50 45 32 13
Sex
 male 43 36 7 0.121
 female 39 26 13
Location
 trunk 47 37 10 0.604
 extremities 35 25 10
Size
 ≥5 cm 59 44 15 1
 <5 cm 23 18 5
Depth
 deep 62 48 14 0.554
 superficial 20 14 6
MVD
 ≥15/HPF 43 34 9 0.607
 <15/HPF 39 28 11
MIB-1
 positive (≥25.8%) 33 23 10 0.223
 negative (<25.8%) 49 39 10
HIF-2α (n = 69)
 positive 24 16 8 0.236
 negative 45 35 10
Necrosis
 No necrosis 38 32 6
 <50% 33 20 13
 ≥50% 11 10 1 0.031*
AJCC stage (n = 81)
 I 24 18 6 0.301
 II 40 30 10
 III 14 12 2
 IV 3 1 2

Abbreviations: MVD = microvessel density; HPF = high power field.

*P <0.05.