Table 1. Association between clinicopathological variables and immunohistochemical detection of HIF-1α.
Variables | Number of patients | HIF-1α | P | |
---|---|---|---|---|
Positive | Negative | |||
Clinical variables (n = 82) | ||||
NF1 | ||||
present | 32 | 22 | 10 | 0.296 |
absent | 50 | 40 | 10 | |
Age | ||||
≥50 | 37 | 30 | 7 | 0.317 |
<50 | 45 | 32 | 13 | |
Sex | ||||
male | 43 | 36 | 7 | 0.121 |
female | 39 | 26 | 13 | |
Location | ||||
trunk | 47 | 37 | 10 | 0.604 |
extremities | 35 | 25 | 10 | |
Size | ||||
≥5 cm | 59 | 44 | 15 | 1 |
<5 cm | 23 | 18 | 5 | |
Depth | ||||
deep | 62 | 48 | 14 | 0.554 |
superficial | 20 | 14 | 6 | |
MVD | ||||
≥15/HPF | 43 | 34 | 9 | 0.607 |
<15/HPF | 39 | 28 | 11 | |
MIB-1 | ||||
positive (≥25.8%) | 33 | 23 | 10 | 0.223 |
negative (<25.8%) | 49 | 39 | 10 | |
HIF-2α (n = 69) | ||||
positive | 24 | 16 | 8 | 0.236 |
negative | 45 | 35 | 10 | |
Necrosis | ||||
No necrosis | 38 | 32 | 6 | |
<50% | 33 | 20 | 13 | |
≥50% | 11 | 10 | 1 | 0.031* |
AJCC stage (n = 81) | ||||
I | 24 | 18 | 6 | 0.301 |
II | 40 | 30 | 10 | |
III | 14 | 12 | 2 | |
IV | 3 | 1 | 2 |
Abbreviations: MVD = microvessel density; HPF = high power field.
*P <0.05.