Table 3. Results of univariate and multivariate analyses for overall survival.
| variable | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95%CI) | P value | HR (95%CI) | P value | |
| NF1 | ||||
| present absent |
1.48 (0.74–2.82) | 0.273 | ||
| 1 | ||||
| HIF-1α | ||||
| positive negative |
2.35 (1.04–6.28) | 0.038* | 8.26 (2.76–28.85) | <0.0001* |
| 1 | 1 | |||
| Age | ||||
| ≥50 <50 |
0.76 (0.38–1.47) | 0.417 | ||
| 1 | ||||
| Sex | ||||
| male female |
1.44 (0.74–2.84) | 0.282 | ||
| 1 | ||||
| Location | ||||
| trunk extremities |
1.90 (0.96–4.04) | 0.065 | 1.43 (0.66–3.23) | 0.367 |
| 1 | 1 | |||
| Size | ||||
| ≥5 cm <5 cm |
3.46 (1.46–10.19) | 0.034* | 2.27 (0.66–9.95) | 0.207 |
| 1 | 1 | |||
| Depth | ||||
| deep superficial |
4.07 (1.59–13.76) | 0.002* | 0.91 (0.23–4.08) | 0.896 |
| 1 | 1 | |||
| MVD | ||||
| ≥15/HPF <15/HPF |
1.88 (0.96–3.82) | 0.066 | ||
| 1 | ||||
| MIB-1 | ||||
| positive negative |
5.59 (2.70–12.23) | <0.0001* | 10.16 (3.60–32.05) | <0.0001* |
| 1 | 1 | |||
| HIF-2α (n = 69) | ||||
| positive negative |
1.16 (0.50–2.48) | |||
| 1 | ||||
| Necrosis | ||||
| No <50% ≥50% |
1 | 1 | ||
| 1.82 (0.90–3.82) | 0.098 | 1.93 | 0.187 | |
| 2.05 (0.65–5.50) | 0.201 | 4.39 | 0.039* | |
| AJCC stage (n = 81) | ||||
| I II III IV |
1 | 1 | ||
| 2.61 (1.11–7.16) | 0.028* | 1.25 (0.41–4.20) | 0.706 | |
| 2.53 (0.79–8.12) | 0.116 | 0.27 (0.06–1.29) | 0.101 | |
| 35.2 (6.63–160.8) | 0.0002* | 17.51 (2.79–100.40) | 0.0036* | |
Abbreviations: HR = hazard ratio; CI = confidence interval.
*P <0.05.