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. 2017 May 15;13(5):e1006722. doi: 10.1371/journal.pgen.1006722

Fig 7. Effects on meiotic recombination of MutLγ mutations in mms4Δ and msh5Δ backgrounds.

Fig 7

Crossover levels within the CEN8-ARG4 interval and chromosome VIII MI nondisjunction frequencies were measured by the fluorescent spore assay. The data of MutLγ mutants in a wild-type background are reproduced from Fig 4 to facilitate comparison. The mlh1 and mlh3 mutants assayed were: mlh1-Nterm (K286E/R289E), mlh3-Nterm (K316E/K320E/R323E), mlh1-Link (K393E/R394E) mlh3-Link (K414E/K416E). A. Crossover levels of MutLγ mutants in wild-type and mms4Δ backgrounds. Error bars represent standard errors. The data were normalized to crossover levels in wild type (11.63 ± 0.63 cM). B. MI nondisjunction frequencies of MutLγ mutants in wild-type and mms4Δ backgrounds. Error bars are 95% confidence intervals of the proportion. C. Crossover levels of MutLγ mutants in wild-type and msh5Δ backgrounds. D. MI nondisjunction frequencies of MutLγ mutants in wild-type and msh5Δ backgrounds. Statistically significant differences are indicated with asterisks (**, p<0.01; ***, p<0.001). Selected non-significant differences are highlighted (n.s.).