| Faglia et al, 199630
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Multiplace hyperbaric chamber at 2.5 ATA in the first phase and 2.2–2.4 ATA in the second phase Patients started as inpatients, so diabetes management is likely to have been better enforced than in studies with patients receiving treatment only as outpatients Met standard wound care guideline requirements (vascular assessment, offloading, infection control, debridement, and dressing changes) Most patients had about 40 HBOT sessions No follow-up time specified |
| Kalani et al, 200234
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Monoplace hyperbaric chamber at 2.5 ATA 5 times a week Nonrandomized, which caused significant differences between groups (age, ID vs. NID, ulcer size) Standard care consisted of assessment and offloading Most patients received 60 HBOT treatments No details of what treatment participants received for 2.5 years after HBOT treatments were finished Follow-up was 3 years
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| Abidia et al, 200328
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Multiplace hyperbaric chamber at 2.4 ATA 5 times a week All patients (except one) had Wagner grade 2 ulcers Met standard wound care guideline requirements (vascular assessment, offloading, infection control, debridement, and dressing changes) Patients received 30 HBOT sessions 3 patients had chronic obstructive pulmonary disease (a contraindication for HBOT) Small sample (8 patients in each arm) Follow-up was 1 year
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| Kessler et al, 200331
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Multiplace hyperbaric chamber at 2.5 ATA; 2 sessions daily, 5 times a week Patients started as inpatients, so diabetes management is likely to have been better enforced than in studies with patients receiving treatment only as outpatients All patients received 20 HBOT sessions Very few baseline characteristics reported Standard care consisted of infection control and offloading Small sample (14 and 13 patients in each arm) Follow-up was 1 month
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| Duzgun et al, 200829
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Monoplace hyperbaric chamber at 2.0 ATA; 2 sessions one day, followed by 1 session the following day (alternating) Standard care consisted of infection control, debridement, and dressing changes Authors did not distinguish patients whose ulcers were a result of ischemia from those whose ulcers were a result of ischemia and prolonged pressure that went undetected owing to neuropathy Outcomes assessed were inconsistent with those assessed in other studies (wound closure through amputation, graft or flap closure, or surgical intervention); further, the study did not identify which patients achieved ulcer closure via each method Defined a minor amputation as either distal or proximal to the metatarsophalangeal joint No follow-up time specified
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| Londahl et al, 201032
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Multiplace hyperbaric chamber at 2.5 ATA 5 times a week All patients had 40 HBOT sessions over a span of up to 10 weeks Met standard wound care guideline requirements (vascular assessment, offloading, infection control, and debridement) Follow-up was 1 year
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| Fedorko et al, 201635
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Monoplace hyperbaric chamber at 2.4 ATA five times a week All patients had about 27 HBOT sessions Standard care consisted of offloading, infection control, and debridement “Prescription for offloading” given, but study did not indicate how many patients fulfilled prescription Did not measure major amputation; used another outcome: “having met criteria for amputation” Follow-up was 3 months
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