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R domain structure is conserved in CbpA sequences from most pneumococcal strains. (A) Phylogenetic tree showing the relationships between 47 CbpA sequences, which cluster into six groups. The TIGR4 sequence is also termed PspC 3.4 (marked by arrow). (B) The histogram illustrates the percentage of amino-acid identity (relative to TIGR4 CbpA) for the R1 and/or R2 domains (R1, blue bars; R2, red bars). Details of this analysis are found in Supplementary data.
