Table 3.

List of “cardioprotective” miRNAs (decreased during TAC and upregulated in TAC LNA-antimiR34 treatment) and their role in the heart based on previous reports.

miRNA	Validated target(s)	Heart related studies
miR-143-3p	Adductin 3 (Add3)*	Increased in human failing hearts.49 Decreased in hearts from mice subjected to MI.27,56 Essential for cardiac chamber morphogenesis and cardiac function.64
miR-186-5p	Unknown	Unknown
miR-378a-5p	IGF1R, Grb2, Mapk1, Ksr1	Increased in human failing hearts.49 Decreased in hearts from mice subjected to MI.27 Decreased in cardiac disease mouse models such as pressure overload 33,52 and overexpression of β1-adrenergic receptor.33 Restoration of miR-378 with AAV attenuated a mouse pressure overload induced hypertrophy and improved cardiac function.33
miR-148b-3p	Unknown	Decreased in mouse hearts subjected to MI.56
miR-335-3p	Unknown	Increased in infarcted mouse hearts.56
miR-194-5p	Unknown	Decreased in mice subjected to MI.56

^*Add3 is important for ventricular cardiomyocyte F-actin remodeling.