Table 3.
LncRNAs involved in immune response.
| LncRNA | Cell involved | Functional mechanism | Associated Disease | Ref. |
|---|---|---|---|---|
| PRINS | Epidermal Cells | Protects cells against stress induced death | Psoriasis | 101 |
| LincRNA-p21 | THP-1 monocytes | Decreased expression induces activity of NFκB | Rheumatoid arthritis | 103 |
| SAS-ZFAT | CD19+ B cells | SNP in SAS-ZFAT promoter region correlates to high risk of autoimmune thyroid disease | Autoimmune thyroid disease | 100 |
| NeST | CD8+ T-cells | Regulates expression of IFNγ by methylation through H3K4 methyltransferase | Microbial infection | 92 |
| GAS5 | T-lymphocytes | Interacts with glucocorticoid receptor and suppresses GR-induced transcriptional activity | Systemic lupus erythematosus | 128 |
| THRIL | THP-1 monocytes | Regulates expression of TNFα via hnRNPL | Kawasaki disease | 99 |
| Lnc-DC | Dendritic cells | Activates transcription factor STAT3 to support cellular differentiation | 93 | |
| Ptprj-as1 | Macrophage | Expressed in response to lipopolysaccharide | 97 |