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The TPR domain does not alter the conformation of the phosphatase domain. (A) Superimposition of the isolated phosphatase domain of Ppp5 (cyan) onto the Ppp5 phosphatase domain (salmon) within full-length Ppp5 shows a small shift of the C-terminal subdomain αJ helix (yellow: full-length Ppp5; orange: isolated Ppp5 domain). (B) Superimposition of the TPR domain of full-length (blue) and isolated protein (green).
