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Hsp90 and Hsp90 peptides activate Ppp5 by binding to its TPR domain. (A) Dose-dependent activation of Ppp5 by full-length yeast Hsp90 and (B) Hsp90 C-terminal peptide. The data plotted are corrected for Ppp5 activity in the absence of activator. ITC plots for Hsp90 peptide interactions with (C) the isolated TPR domain (residues 19–146) and (D) full-length Ppp5.
