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Arachidonoyl-CoA mediates TPR domain unfolding. Arachidonoyl-CoA affects the folding of the isolated TPR domain. The temperature dependence of the CD signal at 222 nm of amino acids 19–147 Ppp5 was recorded in the presence (closed symbols) and absence (open symbols) of 20 μM arachidonoyl-CoA. The melting temperature is increased from 34.6±0.3 to 39.9±0.2°C by the addition of arachidonoyl-CoA, although the apo-state loses helical content (∼15% of CD signal at 222 nm).
