Figure 3.

LC domain mediated RNP assembly in neuronal translational control (A) In the resting state, RNPs formed by interaction of individual RBPs and RNAs, sequester the RNA within RNPs in a translationally repressed state. Upon activity, the RNP disassembles leading to release of suppression resulting in translation of mRNAs with key synaptic functions (B) Models for LC mediated RNP assembly in neurons: in the resting state of synapses, individual RBPs interact by virtue of LC domains that are intrinsically disordered and form either a) transient and reversible amyloid like assemblies or b) reversible aggregates that are formed as result of weak multivalent interactions between LC domains.