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. 2017 May 23;10:2701–2709. doi: 10.2147/OTT.S114318

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© 2017 Liu et al. This work is published and licensed by Dove Medical Press Limited

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MiR-216a promotes the migration, invasion, and EMT of OC cells by suppressing PTEN/AKT pathway.

Notes: (A) Western blot analysis of the expression of PTEN, E-cadherin, Vimentin, p-AKT in CAOV3-miR-216a cells transfected with PTEN vector and control vector; *P<0.05, **P<0.01. (B) Restoration of PTEN in CAOV3-miR-216a cells abrogated the promoting effect of miR-216a mimics on migration and invasion. **P<0.01. (C) Western blot analysis of the expression of PTEN, E-cadherin, Vimentin, p-AKT in SKOV-3-anti-miR-216a cells transfected with PTEN siRNA and negative control vector; *P<0.05, **P<0.01. (D) Inhibition of PTEN in SKOV-3-anti-miR-216a cells reversed the inhibitory effect of miR-216a inhibitor on cell migration and invasion. **P<0.01.

Abbreviations: EMT, epithelial–mesenchymal transition; OC, ovarian cancer; PTEN, phosphatase and tensin homolog; NC, negative control.