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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: Free Radic Biol Med. 2016 Nov 9;102:217–228. doi: 10.1016/j.freeradbiomed.2016.11.008

Fig. 5.

Fig. 5

LPS decreases DDAH activity and increases ADMA levels in pulmonary arterial endothelial cells. PAEC were transduced with AdK295MSrc or AdGFP for 48 h then challenged with LPS (1000 EU/ml; 4 h). Although DDAH II protein levels were unchanged (A), LPS attenuated DDAH (B) activity and increased ADMA levels (B). AdK295MSrc prevented both the decrease in DDAH activity (B) and the increase in ADMA (C). Values are mean ± SEM, n=4–11, * P < 0.05 vs. untreated; †P < 0.05 vs. LPS.