Skip to main content
. 2017 Apr 28;69(6):1246–1256. doi: 10.1002/art.40080

Figure 6.

Figure 6

Low‐density lipoprotein receptor–related protein 1 (LRP‐1)–mediated endocytic pathways in normal and osteoarthritic (OA) cartilage. A, Secreted ADAMTS‐5 and matrix metalloproteinase 13 (MMP‐13) are largely endocytosed by LRP‐1 in normal cartilage. Thus, their activities in the extracellular milieu are limited. B, In OA cartilage, the ectodomain of LRP‐1 is shed by ADAM‐17 and MMP‐14, resulting in impairment of endocytic capacity of chondrocytes. Blocking of ADAM‐17 and MMP‐14 activities recovers the lost endocytic function of OA chondrocytes, reduces cartilage matrix degradation, and restores cartilage homeostasis.