. Author manuscript; available in PMC: 2018 Apr 1.

Published in final edited form as: Curr Opin Immunol. 2017 Feb 1;45:31–36. doi: 10.1016/j.coi.2016.12.002

Table 1.

Regulators of lymphomagenesis in mouse models of B-NHL

Gene	Mutational type	Functional effect	Implications in B-NHL	References
MYC	Gain (CAG; Em)	Growth, Proliferation	BL, tFL, DLBCL	[18]
Pik3ca	Gain (P110^CA)	Growth, Proliferation, Survival	BL	[18]
BCL2	Gain (VavP; Em)	Survival	FL, tFL, DLBCL	[21^••,24^•,25^•,26,31,47^•]
Kmt2d	Loss	Proliferation	FL, tFL, DLBCL	[24^•,25^•]
Crebbp	Loss	Differentiation Block, Proliferation	FL, tFL, DLBCL	[26,48]
Ezh2	Gain (Ezh2^Y641F)	Proliferation, Differentiation Block	FL, tFL, GCB DLBCL	[27,34]
Tet1	Loss	DNA Damage	FL, DLBCL	[28]
Blimp1	Loss	Differentiation Block	ABC DLBCL	[35,36]
Myd88	Gain (Myd88^L252P)	Proliferation, Survival	ABC DLBCL	[38]
Bcl6	Gain (Im)	DNA Damage, Differentiation Block	DLBCL, FL, tFL	[34,39]
Gna13	Loss	Migration, Survival	GCB DLBCL, BL	[46^••]
Hvem	Loss	Proliferation?	FL, tFL, DLBCL	[47^•]