Skip to main content
. Author manuscript; available in PMC: 2018 Sep 15.
Published in final edited form as: Adv Drug Deliv Rev. 2016 Nov 30;119:20–43. doi: 10.1016/j.addr.2016.11.003

Figure 5.

Figure 5

(a) Percent of open wounds evaluated every 2 days post-wounding and treatment with PBAE/VEGF nanoparticle-transfected ASCs, non-modified ASCs or PBS control. (b) Wounds treated with PBAE-pVEGF nanoparticle transfected ASCs showed accelerated closure with full epithelialization observed by day 8. (c) H&E and Masson’s trichrome staining shows increased cellularity and collagen deposition in the dermis treated with ASC-transplanted groups than PBS. (d) The PBAE-pVEGF-transfected ASC-treated group shows the most abundant mature collagen fibers (red-orange), whereas PBS-treated group showed the highest level of immature collagen fibers (green-yellow). Adapted from ref [151] .