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Antitumor efficacy following systemic delivery of guanidine-cyclodextrin-PEG-anisamide (G–CD–PEG–AA)-siVEGF complex evaluated by (a) tumor volume, (b) VEGF mRNA knockdown, and (c) body weight concurrent with tumor treatments. Liver enzyme levels, (d) aspartate aminotransferase (ASAT) and (e) alanine aminotransferase (ALAT) (mean ± SD shown; NS = no significance, *p < 0.05). Adapted from ref [228]
