. 2017 Apr 11;475(7):1767–1774. doi: 10.1007/s11999-017-5302-0

Table 1.

Pharmacokinetic equations used to determine vancomycin peak levels at the start of the procedure and at the end

Estimated creatinine clearance (CrCl) by Cockroft-Gault equation, mL/min	CrCl (male) = [(140 − age) × ideal body weight (IBW)]/(72 × SCr^*)
	CrCl (female) = [(140 − age) × IBW (kg)]/(72 × SCr_*) × 0.85
	IBW (males), kg = 50 + (2.3 × height in inches over 60 inches)
	IBW (females), kg = 45 + (2.3 × height in inches over 60 inches)
Vancomycin clearance (clearance), L/h	Clearance = CrCl × 0.06
Vancomycin volume of distribution (Vd), L	Vd = DW × 0.7 L/kg
Vancomycin Ke, h⁻¹	Ke = Cl/Vd
Vancomycin half-life (T_1/2), h	T_1/2 = 0.693/Ke
Estimated peak level (Cmax), mg/L	Cmax = dose^†/Vd
Estimated level at the end of surgical procedure (Cmin), mg/L	Cmin = Cmax × e^−Ke×T

Adapted and slightly modified from Catanzano et al. [9]; *used minimum serum creatinine of 1 mg/dL if age > 65 years; ^†dose = actual vancomycin dose given to the patient or calculated weight-based dose (15 mg/kg × DW, rounded to the nearest 250 mg); IBW = ideal body weight; Scr = serum creatinine; DW = dosing weight (total actual body weight in kg); Ke = elimination rate constant; T = operative time in hours.