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. 2017 May 30;7:2476. doi: 10.1038/s41598-017-02823-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(a) CDC of Raji cells incubated with a fixed 10 μg/mL concentration of the indicated mmIgG1 (left), mmIgG2a (middle), or mmIgG2b (right) variants of mAb 7D8 in the presence of 20% (v/v) pooled human serum. (b) Surrogate ADCC activity of Jurkat-NFAT-mFcγRIV effector (E) cells induced by Raji target (T) cells incubated with a fixed 3 μg/mL concentration of the indicated variants (see A), with an E:T ratio of 1:1. (c) Phagocytosis of Daudi cells (T) by bone marrow-derived mouse macrophages (E) incubated with a fixed 1 μg/mL concentration of the indicated variants (see A), with an E:T ratio of 1:1. Data represent mean ± SEM of at least three experiments. Statistical significance (compared to WT) was determined by one-way ANOVA (***P < 0.001; ****P < 0.0001).