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. 2017 May 30;7:2476. doi: 10.1038/s41598-017-02823-9

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Evaluation of in vivo toxicity in a syngeneic B16-F10 xenograft model. Mice were dosed as described in Fig. 6B with the indicated bsAb variants. (a) Bodyweight followed over time (grey arrowheads indicate treatment days; red arrowhead indicates blood sampling). Data represent mean bodyweight ± SEM. (b) Cytokine concentrations at 1–2 h after the first dose. Data represent individual mice & mean ± SD. Statistical significance (compared to PBS control group) was determined by one-way ANOVA (**P < 0.01; ***P < 0.001; ****P < 0.0001).