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. 2017 May 30;7:2509. doi: 10.1038/s41598-017-01737-w

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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ApoE3 native and variants trajectories analyses. In Backbone RMSD variation the variants are identified in the plots by different colors (A). Radius of gyration (B), solvent accessible surface area (C) and number of hydrogen bonds (D) are plotted in boxplots. On backbone RMSD (A) the variants are identified in the plots by colors: Native structure (black), Pro102Arg (red), Arg132Ser (green), Arg176Cys (blue) and Trp296Cys (turquoise). Only the number of hydrogen bonds between NT and CT domains was computed (D). Dotted red lines on solvent accessible surface area, radius of gyration and number of hydrogen bonds plots indicate the reference values of wild type. The solvent accessible surface and radius of gyration values are in nm² and to RMSD values in Å.