Table 3.
Correlation analysis between histological necrosis and radiological response according to modified Response Evaluation Criteria in Solid Tumours and European Association for the Study of the Liver criteria n (%)
|
Overall response |
Target lesion response |
|||||||
| Patients (n) |
% of necrosis on CTA |
Patients (n) |
% of necrosis on CTA1 |
|||||
| 100 | 50-99 | < 50 | 100 | 50-99 | < 50 | |||
| mRECIST | ||||||||
| Complete response | 24 | 13 (54.2) | 8 (33.3) | 3 (12.5) | 29 | 16 (55.2) | 8 (27.6) | 5 (17.2) |
| Partial response | 26 | 1 (3.8) | 19 (73.1) | 6 (23.1) | 25 | 2 (8.0) | 16 (64.0) | 7 (28.0) |
| Stable/progressive disease | 20 | 0 (0.0) | 1 (5.0) | 19 (95.0) | 16 | 0 (0.0) | 0 (0.0) | 16 (100.0) |
| EASL | ||||||||
| Complete response | 24 | 13 (54.2) | 8 (33.3) | 3 (12.5) | 29 | 16 (55.2) | 8 (27.6) | 5 (17.2) |
| Partial response | 25 | 1 (4.0) | 17 (68.0) | 7 (28.0) | 25 | 1 (4.0) | 15 (60.0) | 9 (36.0) |
| Stable/progressive disease | 21 | 0 (0.0) | 3 (14.3) | 18 (85.7) | 16 | 1 (6.3) | 1 (6.3) | 14 (87.5) |
1
For radio-histological correlation of the target lesion response, the percentage of necrosis on CTA was re-calculated considering only nodules ≥ 1 cm in diameter. CTA: Cumulative Tumour Area; mRECIST: Modified Response Evaluation Criteria in Solid Tumours; EASL: European Association for the Study of the Liver.