Table 4.
Results of meta-analysis comparison of minimally invasive living donor hepatectomy and conventional living donor hepatectomy
| Outcome of interest | Study (n) | MILDH (n) | CLDH (n) | WMD/OR (95%CI) | P value |
Study heterogeneity |
P value | ||
| I2 | df | I2, % | |||||||
| Graft weight (g) | 5 | 123 | 119 | -3.32 (-22.25,15.61) | 0.73 | 6.56 | 4 | 39 | 0.16 |
| Donor outcomes | |||||||||
| Operative time (min) | 13 | 476 | 1116 | 20.68 (-6.25,47.60) | 0.13 | 147.62 | 12 | 92 | < 0.01 |
| Estimated blood loss (mL) | 12 | 450 | 1092 | -32.61 (-80.44,15.21) | 0.18 | 61.26 | 11 | 82 | < 0.01 |
| Hospital cost (dollar) | 2 | 36 | 36 | 0.56 (-0.62,1.74) | 0.35 | 4.24 | 1 | 76 | 0.04 |
| Length of hospital stay (d) | 10 | 392 | 575 | -1.25 (-2.35,-0.14) | 0.03 | 99.31 | 9 | 91 | < 0.01 |
| Post complications | 12 | 451 | 632 | 0.62 (0.44,0.89) | 0.009 | 4.40 | 11 | 0 | 0.96 |
| Analgesic use (h) | 5 | 139 | 167 | -7.97 (-14.06,-1.87) | 0.01 | 7.50 | 4 | 47 | 0.11 |
| Liver function | |||||||||
| Post AST peak (IU/L) | 7 | 334 | 471 | 6.41 (-3.79.16.60) | 0.22 | 13.60 | 6 | 56 | 0.03 |
| Post ALT peak (IU/L) | 8 | 350 | 485 | 11.86 (-10.84,34.57) | 0.31 | 15.39 | 7 | 55 | 0.03 |
| Post TB peak (mg/dL) | 7 | 324 | 461 | -0.10 (-0.26,0.06) | 0.21 | 2.10 | 6 | 0 | 0.91 |
| Recipient outcomes | |||||||||
| Liver function | |||||||||
| Post AST peak (IU/L) | 3 | 59 | 59 | -28.73 (-86.76,29.31) | 0.33 | 0.90 | 2 | 0 | 0.64 |
| Post ALT peak (IU/L) | 3 | 59 | 59 | -29.98 (-87.65,27.7) | 0.31 | 0.31 | 2 | 0 | 0.86 |
| Post TB peak (mg/dL) | 3 | 59 | 59 | -0.96 (-2.57,0.65) | 0.24 | 1.26 | 2 | 0 | 0.53 |
| Surviving | 3 | 0.96 (0.27,3.47) | 0.95 | 0.11 | 2 | 0 | 0.95 | ||
| Post complications | 6 | 272 | 375 | 0.93 (0.66,1.31) | 0.68 | 3.28 | 5 | 0 | 0.66 |
MILDH: Minimally invasive living donor hepatectomy; CLDH: Conventional living donor hepatectomy; WMD/OR: Weight mean difference/odds ratio; df: Degree of freedom; Post: Postoperative.