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. 2017 May 31;9:141. doi: 10.3389/fnagi.2017.00141

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Copyright © 2017 Castano-Prat, Perez-Zabalza, Perez-Mendez, Escorihuela and Sanchez-Vives.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Oscillatory activity in the PrL (prefrontal) cortex of a senescence accelerated mouse resistance 1 (SAMR1; control) mouse under ketamine anesthesia. (A) Spontaneous extracellular activity in deep layers was recorded simultaneously in both hemispheres for each cortical area (prelimbic, PrL; primary motor, M1; primary somatosensory, S1; and primary visual, V1). (B) Top: raw local field potential (LFP) from the right PrL cortex of a SAMR1 mouse showing the alternating Up (active) and Down (silent) states. Bottom: spectrogram showing the presence of high frequency rhythms, mainly during the Up states. (C) Waveform average of the mean multiunit activity (MUA) signal aligned at the Down-to-Up state transition (dashed line at time 0). This average is used for the calculation of the maximum (red square) firing rate (FR; see the “Materials and Methods” Section for further details). The shade corresponds to the SD.