Table 2.

Biochemical dysregulations in diabetic cardiomyopathy.

Functional and metabolic outcomes	Type 1 diabetes					Type 2 diabetes
	STZ	OVE26	BB	NOD	Alloxan	Akita	ob/ob	db/db	ZDF
Inflammation	↑	↑	↑	↑	↑	↑	↑	↑	↑
Cardiac size	=	=	=	↑	=	↓	↑	↑	↑
Cardiac function	↓	↓	↓	↓	↓	↓	↑/↓	↓	↓
Cardiac efficiency	↓	=	=	↓	↓	=	↓	↓	=
Mitochondrial energetics	↓	↓	↓	=	↓	↓	↓	↓	=
Lipid storage	↑	=	=	↑	=	=	↑	↑	↑
Fatty acid oxidation	↑	=	=	↑	=	↑	↑	↑	↑
Glucose oxidation	↓	=	=	=	=	↓	↓	↓	↓

Up and down arrows indicate increase and decrease, respectively; =, indicates no change.

OVE26, beta-cell overexpression of calmodulin; NOD, non-obese diabetic; STZ, streptozotocin; ZF/ZDF, Zucker fatty/Zucker diabetic fatty rats.