Histopathologic scores of lung sections of C57BL/6 wild-type young and mature mice (n = 4–10 mice for each group). Lung injury was scored from 0 (no damage) to 16 (maximal damage). (A) Box plots represent 25th percentile, median, and 75th percentile; error bars define 10th and 90th percentiles; whiskers define minimal and maximal values. (B) Lung myeloperoxidase activity, (C) lung wet to dry weight ratio, and BAL fluid (BALF) analysis of (D) total protein content, (E) total count of viable inflammatory cells, and (F) IL-6 levels in C57BL/6 wild-type young and mature mice. Data represent the mean ± SEM of 4–10 animals per group. *P < 0.05 versus age-matched control mice; #P < 0.05 versus vehicle-treated group of the same age; ‡P < 0.05 versus young group.