Figure 6.

Bitter taste receptor agonist chloroquine-induced reduction in cell stiffness of isolated ASM cells was reduced in gelsolin KO mice. Cell stiffness was measured for 30 seconds after each increment of drug addition at 1-minute intervals, which was normalized to baseline stiffness before addition of chloroquine (n = 289–438 cells; ****P < 0.0001, **P < 0.01). EC₅₀ for chloroquine for WT and gelsolin KO cells were 0.171 and 8.43 mM, respectively. Data are presented as mean (±SEM).