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. 2017 May 31;8:335. doi: 10.3389/fphys.2017.00335

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Copyright © 2017 Uslusoy, Nazıroğlu and Çiğ.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of Hypericum perforatum (HP) treatment on [Ca²⁺]_i concentration and TRPV1 in sciatic nerve (A) and dorsal root ganglion neuron (DRGN) (B) of control, sham and SNI-induced rats. (n = 8 and mean ± SD). The animals received oral HP for 4 weeks. Then, these dissected neurons of control, sham and SNI were further in vitro treated with CAPS (0.01 mM) and CapZ (0.1 mM) before loading Fura-2 for 125 s. ^ap ≤ 0.05 and ^bp ≤ 0.001 vs. control and sham groups. ^cp ≤ 0.05 and ^dp ≤ 0.001 vs. sham+CapZ and sham+HP groups. ^ep ≤ 0.001 vs. sham+HP+CapZ group. ^fp ≤ 0.001 vs. SNI group. ^gp ≤ 0.05 and ^hp ≤ 0.001 vs. SNI+CapZ group. ^kp ≤ 0.05 vs. SNI+HP group (C).