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. 2017 May 31;8:335. doi: 10.3389/fphys.2017.00335

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Copyright © 2017 Uslusoy, Nazıroğlu and Çiğ.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Graphical Abstract — Poly (ADP-ribose) polymerase (PARP) catalyzes the transfer of ADP-ribose (ADPR) in nucleus during the DNA repair processes. TRPM2 channel is gated by ADPR and reactive oxygen species (ROS) through activation of ADP-ribose (ADPR) pyrophosphate enzyme in its nudix domain motif although it was inhibited by N-(p-amylcinnamoyl)anthranilic acid (ACA). TRPV1 channel is also activated by ROS and capsaicin (CAPS) but it is inhibited by capsazepine (CapZ).