Table 4.
Signalment and presenting clinical signs in 25 dogs with acute myeloid leukemia in which clonality testing was performed.
| Dog | Breed | Age (years) | Sex | Clinical signs |
|---|---|---|---|---|
| 1 | Springer Spaniel | 9.7 | MN | Vomiting, straining to defecate, dyspnea, fever |
| 2 | German Shepherd dog | 6.5 | MN | Weight loss (10 kg), inappetence, diarrhea, hepatosplenomegaly |
| 3 | German Shepherd dog | 10 | FS | Polydipsia, inappetence, fever, firm lymph nodes, splenomegaly |
| 4 | Boxer | 8 | FS | Neurologic disease |
| 5 | Collie | 5 | FS | Anemia, hepatosplenomegaly |
| 6 | Golden Retriever | 8 | MN | Anorexia, vomiting, moderate peripheral lymphadenopathy |
| 7 | Mixed breed | 11 | MN | Inappetence, splenomegaly, leukocytosis |
| 8 | Great Dane | 7.5 | MN | Moderate to marked peripheral lymphadenopathy (mandibular, prescapular), diagnosed as non-B non-T lymphoma on prior lymph node aspirate and biopsy |
| 9 | Boxer | 3 | FS | Fever, splenomegaly |
| 10 | Labrador Retriever | 3.5 | FS | Prior diagnosis of “lymphoblastic leukemia,” splenomegaly |
| 11 | Labrador cross | 8 | MN | Dyspnea, “lymphocytosis,” mild peripheral lymphadenopathy |
| 12 | German Shepherd dog | 9 | MN | Anorexia, lethargy, marked “monocytosis” |
| 13 | Golden Retriever | 11 | MN | Routine seizure check, neoplastic cells noted in circulation |
| 14 | Bernese Mountain dog | 2 | MN | Thrombocytopenia evaluation |
| 15 | Labrador Retriever | 10 | MN | Vomiting, diarrhea, “lymphocytosis,” mild to moderate peripheral lymphadenopathy |
| 16 | Rottweiler | 9 | FS | Vomiting, inappetence, moderate peripheral and thoracic lymphadenopathy, hepatosplenomegaly |
| 17 | Cavalier King Charles Spaniel | 6 | FS | Leukocytosis, pleural effusion, mild peripheral lymphadenopathy |
| 18 | Labrador Retriever | 8 | MN | Inappetence, straining to defecate and liquid diarrhea, one vomiting episode, marked leukocytosis |
| 19 | Labrador Retriever | 4 | MN | Acute collapse, pancytopenia, hepatosplenomegaly |
| 20 | West Highland White Terrier | 3 | MN | Anorexia, lethargy, pancytopenia |
| 21 | Border Collie mix | 10 | MN | Mandibular lymphadenopathy, mild abdominal lymphadenopathy and splenomegaly |
| 22 | Rottweiler | 1.9 | F | Mandibular and popliteal lymphadenopathy, moderate hepatosplenomegaly |
| 23 | Labrador Retriever | 2 | M | Anemia, prescapular and popliteal lymphadenopathy, ascites |
| 24 | Mixed breed | 12 | FS | Seizures, hypoglycemia, large buffy coat |
| 25 | Labradoodle | 9 | MN | Moderate popliteal lymphadenopathy |
F, intact female; FS, female spayed; M, intact male; MN, male neutered.
Underlined dog numbers were included in our previous publication on ALP staining in acute myeloid leukemia (16). Case 2 was also presented in the February 2015 American Society of Veterinary Clinical Pathology on-line rounds (available to members only at https://www.asvcp.org/).