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Diagram of β4 integrin–mediated motility. In β4 integrin–expressing cells, α6β4 integrin induces Rac1 activation, which leads to directed migration. In β4 integrin–deficient cells, α6 integrin partners with β1 integrin and does not activate Rac1. Thus, β4 integrin–deficient cells do not exhibit directed migration. FA β1 integrin, focal adhesion β1 integrin.
