Table 1.
Baseline averages of mean arterial pressure (MAP), heart rate (HR), respiratory rate (RR), and activity recorded for 5 day prior to the start of the intermittent hypoxia protocol in rats that were injected in the MnPO with AAVs containing either scrambled shRNA (SCM) or shRNA targeting ACE1 (ACE1) and later exposed to either 7 days of normoxia (Norm) or intermittent hypoxia (CIH)
| n | MAP (mmHg) | HR (bpm) | RR (bpm) | Activity (cpm) | ||
|---|---|---|---|---|---|---|
| SCM Norm | 14 | 0800‐1600 | 96 ± 2.3 | 330 ± 6 | 100 ± 1 | 1.5 ± 0.1 |
| 1800‐0600 | 03 ± 2.6 | 385 ± 7 | 100 ± 1 | 5.9 ± 0.5 | ||
| SCM CIH | 11 | 0800‐1600 | 95 ± 1.2 | 320 ± 6 | 97 ± 1 | 1.0 ± 0.1 |
| 1800‐0600 | 99 ± 1.1 | 379 ± 6 | 99 ± 1 | 4.5 ± 0.4 | ||
| ACE1 Norm | 11 | 0800‐1600 | 94 ± 1.9 | 319 ± 4 | 98 ± 1 | 1.0 ± 0.1 |
| 1800‐0600 | 100 ± 2.4 | 386 ± 7 | 96 ± 1 | 5.1 ± 0.4 | ||
| ACE1 CIH | 8 | 0800‐1600 | 94 ± 2.5 | 322 ± 4 | 98 ± 1 | 1.1 ± 0.2 |
| 1800‐0600 | 99 ± 2.7 | 384 ± 5 | 98 ± 1 | 4.3 ± 0.4 | ||
| ACE1 CIH Miss | 8 | 0800‐1600 | 98 ± 1.9 | 321 ± 6 | 100 ± 2 | 0.9 ± 0.1 |
| 1800‐0600 | 102 ± 1.8 | 381 ± 7 | 101 ± 1 | 3.9 ± 0.3 |
Rats with AAV‐shACE1 injections that did not include the MnPO were used to form a separate control group (AC1 CIH Miss). The times in the table correspond to the time of days when the intermittent hypoxia occurred (0800‐1600) or the normoxic dark phase (1800‐0600). There were no significant differences among the groups for any of the variables.