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. 2017 Apr 28;45(10):5930–5944. doi: 10.1093/nar/gkx317

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© The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 6. — MiR-7-loaded TRAIL-MSCs specifically migrate to cancer cells. (A) The migration ability of MSCs with different modification toward cancer cell lines at 6 h as determined from transwell assay in vitro. HEK-293A cell was used as a control to better mimic the normal cell lines. Representative photomicrographs of stained filters showing migrated MSCs or modified MSCs. (B) Immunohistochemical (IHC) analysis of tumor tissues showing the migration ability of miR-7-loaded TRAIL-MSCs in vivo. Tumor tissues were harvested 16 h after tail vein injection using modified MSCs. **P < 0.01, ***P < 0.001; one-way ANOVA, mean ± SD, n = 3.