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. 2017 May 2;45(10):5995–6010. doi: 10.1093/nar/gkx325

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© The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 3. — Deficiency of topo IIα and topo IIβ impairs the decatenation checkpoint in HL-60 and MEF cells. (A) Pseudomitotic index of HL-60 cells stably transfected with shRNAs targeted to GFP (HL60/si-GFP), topo IIα (HL60/si-topo IIα) or topo IIβ (HL60/si-topo IIβ). Columns represent the mean of three biological replicates and the bars indicate standard deviations. *P < 0.05, ***P < 0.001, ****P < 0.0001 (two-sample t-test was used to compare data sets). (B) Pseudomitotic index of parental HL-60, HL-60/AMSA-R/vector or HL-60/AMSA-R/topo IIβ cells. Columns represent the mean of three biological replicates and the bars indicate standard deviations. **P < 0.01 (two-sample t-test was used to compare data sets). (C) Pseudomitotic index of MEF topo IIβ +/+ and topo IIβ -/- cells. Columns represent the mean of three biological replicates and the bars indicate standard deviations. *P < 0.05 (two-sample t-test was used to compare data sets).