Table 2. Heat regulation by HSF1—results obtained based on HSF1 depletion or HSF1 inhibition.

Regulation by HSF1	RNA levels after heat treatment
	Increased			Decreased
Cell type	HeLa	HeLa	HF73*	HeLa	HeLa	HF73
No regulation	336 (65.8%)	176 (34.4%)	167 (38.5%)	802 (61.5%)	292 (71.9%)	123 (55.9%)
Negative regulation	38 (7.4%)	7 (1.4%)	39 (9.0%)	272 (20.8%)	87 (21.4%)	65 (29.6%)
Positive regulation	137 (26.8%)	328 (64.2%)	228 (52.5%)	231 (17.7%)	27 (6.7%)	32 (14.5%)
	HSF1 siRNA depletion**	IHSF115 inhibition (present study)		HSF1 siRNA depletion**	IHSF115 inhibition (present study)

*HSF2-deficient HeLa-derived line.

**The depletion data are from ref. 29.