Table 1.
Demographics of patients undergoing preoperative chemotherapy with either MAGIC or OE02-type drugs as well as of those receiving surgery alone during the matching time periods
| Chemotherapy | Surgery alone | |||||
| OE02 (n=97) | MAGIC (n=275) | p-value | OE02 era (n=144) | MAGIC era (n=196) | p-value | |
| Median age in years (IQR) | 63.0 (57.0–69.0) | 64.0 (58.2–70.1) | 0.233* | 73.0 (64.5–77.5) | 75.0 (67.0–79.0) | 0.027* |
| >70 years | 23.7% | 28.0% | – | 59.7% | 67.8% | – |
| Male | 87.6% | 85.8% | – | 86.8% | 79.9% | – |
| 30-day mortality | 3.1% | 2.2% | 0.702** | 7.2% | 6.9% | 0.536** |
| Oesophageal cancer | 25 (25.8%) | 109 (39.6%) | 0.009** | 30 (20.8%) | 80 (40.8%) | <0.001** |
| GOJ cancer | 72 (74.2%) | 166 (60.4%) | 114 (79.2%) | 116 (59.2%) | ||
| Stage 0 | 1 (1.0%) | 9 (3.3%) | 0.022 † | 0 (0%) | 3 (1.5%) | 0.032† |
| Stage 1 | 9 (9.3%) | 54 (19.6%) | 23 (16.0%) | 42 (21.4%) | ||
| Stage 2 | 25 (25.8%) | 53 (19.3%) | 57 (39.6%) | 50 (25.5%) | ||
| Stage 3 | 57 (58.8%) | 155 (56.4%) | 62 (43.1%) | 100 (51.0%) | ||
| Stage 4 | 5 (5.2%) | 4 (1.5%) | 2 (1.4%) | 1 (0.5%) | ||
| TRG 1–3 | 20 (28.2%) | 82 (30.9%) | 0.384† | N/A | – | |
| TRG 4 and 5 | 51 (71.8%) | 183 (69.1%) | ||||
| TRG not recorded | 26 (26.8%) | 10 (3.6%) | – | N/A | – | |
| Mean cycles of preoperative chemotherapy | 1.95 | 2.86 | <0.001 ‡ | N/A | – | |
| Mean cycles of postoperative chemotherapy | 0 | 1.37 | – | N/A | – | |
| Mean total cycles of chemotherapy | 1.95 | 4.24 | <0.001‡ | N/A | – | |
GOJ = gastro-oesophageal junction; IQR = interquartile range; TRG = tumour regression grade
*Mann–Whitney U test; **Fisher’s exact test; † chi-squared test; ‡t-test