Table 1.
Auxological data and hormonal test results in GHD children and in controls.
| Group | GHD | Controls |
|---|---|---|
| Number of children (girls/boys) | 26 (11/15) | 39 (12/27) |
| Chronological age (years) | 10.91 ± 2.55 | 10.87 ± 3.12 |
| Height SDS | −2.53 ± 0.56a | −0.58 ± 1.11a |
| BMI (kg/m2) | 18.51 ± 3.64 | 18.23 ± 3.51 |
| BMI SDS for CA | 0.37 ± 1.47 | 0.15 ± 1.12 |
| BMI SDS for HA | 0.94 ± 1.70b | 0.31 ± 1.14b |
| IGF-I (ng/ml) | 184.18 ± 85.61 | 208.13 ± 123.77 |
| IGF-I SDS | −1.21 ± 0.90b | −0.29 ± 1.03b |
| IGFBP-3 (μg/ml) | 4.49 ± 1.28 | 4.65 ± 1.10 |
| IGF-I/IGFBP-3 molar ratio | 0.25 ± 0.12 | 0.24 ± 0.14 |
| Ghrelin (pg/ml) | 1352.03 ± 715.75b | 1064.10 ± 493.39b |
| Leptin (ng/ml) | 13.09 ± 11.72b | 7.74 ± 9.14b |
| Adiponectin (ng/ml) | 19.18 ± 12.58 | 17.71 ± 8.12 |
| Resistin (ng/ml) | 9.44 ± 2.90b | 12.68 ± 6.33b |
| Triglycerides (mg/dl) | 84.71 ± 34.17b | 63.47 ± 26.64b |
| Total cholesterol (mg/dl) | 171.70 ± 33.91 | 162.00 ± 31.60 |
| LDL cholesterol (mg/dl) | 96.63 ± 31.43 | 86.79 ± 23.96 |
| HDL cholesterol (mg/dl) | 60.19 ± 14.21 | 62.84 ± 15.65 |
| Glucose 0′ (mg/dl) | 84.29 ± 8.01 | 85.10 ± 6.24 |
| Insulin 0′ (uIU/ml) | 7.67 ± 4.20 | 6.93 ± 4.16 |
| IRI HOMA | 1.70 ± 0.99 | 1.47 ± 0.93 |
Data are presented as the means ± SD. GHD: growth hormone deficiency; SDS: standard deviation score; BMI: body mass index; CA: chronological age; HA: height age; IGF-I: insulin-like growth factor I; IGFBP-3: insulin-like growth factor binding protein 3; LDL-cholesterol: low density lipoprotein-cholesterol; HDL-cholesterol: high density lipoprotein-cholesterol; IRI HOMA: insulin resistance index according to homeostasis model assessment. In the individual rows of the table, the variables designated with the same letters differ significantly from each other with ap < 0.00000 and bp < 0.05. One-way analysis of variance (ANOVA) was used for group comparison.