Table 3.
Auxological data and hormonal tests results in GHD children with lower IGF-I bioavailability and in GHD children with higher IGF-I bioavailability.
| GHD children with lower IGF-I bioavailability | GHD children with higher IGF-I bioavailability | |
|---|---|---|
| Number of children (girls/boys) | 14 (6/8) | 12 (5/7) |
| Chronological age (years) | 10.24 ± 2.37 | 11.99 ± 2.42 |
| Height SDS | −2.42 ± 0.48 | −2.66 ± 0.63 |
| BMI (kg/m2) | 16.54 ± 2.53b | 20.65 ± 3.51b |
| BMI SDS for CA | −0.21 ± 1.43d | 0.99 ± 1.31d |
| BMI SDS for HA | 0.13 ± 1.44c | 1.81 ± 1.55c |
| GHmax after clonidine (ng/ml) | 7.06 ± 1.88 | 7.64 ± 1.80 |
| GHmax after glucagon (ng/ml) | 4.50 ± 1.56d | 7.33 ± 2.85d |
| GHmax during nocturnal profile | 8.83 ± 5.41 | 7.34 ± 3.53 |
| IGF-I (ng/ml) | 133.33 ± 54.22a | 243.50 ± 77.79a |
| IGF-I SDS | −1.79 ± 0.63b | −0.67 ± 0.79b |
| IGFBP-3 (μg/ml) | 4.46 ± 1.17 | 4.52 ± 1.42 |
| IGF-I/IGFBP-3 molar ratio | 0.16 ± 0.07b | 0.32 ± 0.11b |
| Triglicerides (mg/dl) | 68.14 ± 28.34d | 96.30 ± 34.32d |
| Total cholesterol (mg/dl) | 169.89 ± 31.15 | 173.18 ± 37.46 |
| LDL cholesterol (mg/dl) | 105.43 ± 22.16 | 89.78 ± 36.92 |
| HDL cholesterol (mg/dl) | 62.17 ± 13.95 | 59.00 ± 14.98 |
| Ghrelin (pg/ml) | 1648.95 ± 657.60d | 1005.64 ± 640.44d |
| Leptin (ng/ml) | 9.82 ± 8.20 | 16.06 ± 13.93 |
| Adiponectin (ng/ml) | 23.72 ± 6.3d | 15.06 ± 6.18d |
| Resistin (ng/ml) | 8.70 ± 2.51 | 10.11 ± 3.18 |
| Glucose 0′ (mg/dl) | 84.86 ± 4.49 | 83.90 ± 10.00 |
| Insulin 0′ (uIU/ml) | 5.92 ± 4.43d | 9.07 ± 3.63d |
| IRI HOMA | 1.36 ± 1.04d | 1.93 ± 0.94d |
Data are presented as the means ± SD. GHD: growth hormone deficiency; SDS: standard deviation score; BMI: body mass index; CA: chronological age; HA: height age; IGF-I: insulin-like growth factor I; IGFBP-3: insulin-like growth factor binding protein 3; LDL-cholesterol: low density lipoprotein-cholesterol; HDL-cholesterol: high density lipoprotein-cholesterol; IRI HOMA: insulin resistance index according to homeostasis model assessment. In the individual rows of the table, the variables designated with the same letters differ significantly from each other with ap < 0.0005, bp < 0.005, cp < 0.01, and dp < 0.05. One-way analysis of variance (ANOVA) was used for group comparison.